Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes was written by McCoull, William;Addie, Matthew S.;Birch, Alan M.;Birtles, Susan;Buckett, Linda K.;Butlin, Roger J.;Bowker, Suzanne S.;Boyd, Scott;Chapman, Stephen;Davies, Robert D. M.;Donald, Craig S.;Green, Clive P.;Jenner, Chloe;Kemmitt, Paul D.;Leach, Andrew G.;Moody, Graeme C.;Morentin Gutierrez, Pablo;Newcombe, Nicholas J.;Nowak, Thorsten;Packer, Martin J.;Plowright, Alleyn T.;Revill, John;Schofield, Paul;Sheldon, Chris;Stokes, Steve;Turnbull, Andrew V.;Wang, Steven J. Y.;Whalley, David P.;Matthew Wood, J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Synthetic Route of C14H11NOS This article mentions the following:
A novel series of DGAT-1 inhibitors was discovered from an oxadiazole amide high throughput screening (HTS) hit. Optimization of potency and ligand lipophilicity efficiency (LLE) resulted in a carboxylic acid containing clin. candidate 53 (AZD3988, I), which demonstrated excellent DGAT-1 potency (0.6 nM), good pharmacokinetics and pre-clin. in vivo efficacy that could be rationalised through a PK/PD relationship. In the experiment, the researchers used many compounds, for example, 3-Benzyloxyphenylisothiocyanate (cas: 206559-36-6Synthetic Route of C14H11NOS).
3-Benzyloxyphenylisothiocyanate (cas: 206559-36-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C14H11NOS
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics