A simple and facile method for the synthesis of 1-octacosanol was written by Kunkuma, Vijaya Lakshmi;Kaki, Shiva Shanker;Rao, Bhamidipati V. S. K.;Prasad, Rachapudi B. N.;Prabhavathi Devi, Bethala L. A.. And the article was included in European Journal of Lipid Science and Technology in 2013.Application of 106-79-6 This article mentions the following:
An efficient synthetic method was developed for the preparation of 1-octacosanol (C28-alc., long-chain aliphatic alc., higher alc.) (I) from com. available lipid-based intermediates namely sebacic acid (decanedioic acid) and stearyl alc. (1-octadecanol). The key step in the synthesis was a Wittig reaction. This product on simultaneous hydrogenation of double bond and deprotection of tert-butyldimethylsilyl protecting group in a single step on treatment with Pd/C and H2 in methanol at ambient temperature resulted octacosanol in 95% yields. The products were characterized by IR, 1H NMR, and GC-MS anal. The synthesis of the target compound was achieved by a Wittig reaction of (octadecyl)triphenylphosphonium bromide with 10-[[(1,1-dimethylethyl)dimethylsilyl]oxy]decanal, formation of an alkene and subsequent reduction In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6Application of 106-79-6).
Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Application of 106-79-6
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