The Synthesis of a Terminally Linked Homodimeric Bisdistamycin Analog was written by Al-Said, Naim H.. And the article was included in Monatshefte fuer Chemie in 2006.Synthetic Route of C7H8N2O4 This article mentions the following:
A practical synthetic route to a terminally linked homodimeric bisdistamycin analog is described. In this analog the two strands of tricarboxamides of the pyrrole-pyrrole-pyrrole array are tethered from the nitrogen atom of the terminal pyrrole by a bis(ethoxyethane)chain. In the experiment, the researchers used many compounds, for example, Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7Synthetic Route of C7H8N2O4).
Ethyl 4-nitro-1H-pyrrole-2-carboxylate (cas: 5930-92-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Synthetic Route of C7H8N2O4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics