Design, Synthesis, and Structure-Activity Relationship of a Novel Series of GluN2C-Selective Potentiators [Erratum to document cited in CA160:398927] was written by Zimmerman, Sommer S.;Khatri, Alpa;Garnier-Amblard, Ethel C.;Mullasseril, Praseeda;Kurtkaya, Natalie L.;Gyoneva, Stefka;Hansen, Kasper B.;Traynelis, Stephen F.;Liotta, Dennis C.. And the article was included in Journal of Medicinal Chemistry in 2015.Safety of Methyl 2-methoxy-4-methylbenzoate This article mentions the following:
On page 2341, compound 162 in Table 4 should have an isonicotinoyl group in the R1 position instead of a Me group. On page 2345, compounds 159 and 160 in Table 3 should have a Me group in the 2-position of the indole, and the R1 should be a Me group instead of the nicotinoyl group shown. After rechecking the purity of all reported compounds, compounds 66-68, 85, 89, 90, 100, and 112 did not meet the J. Med. Chem. purity standards In the experiment, the researchers used many compounds, for example, Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1Safety of Methyl 2-methoxy-4-methylbenzoate).
Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Safety of Methyl 2-methoxy-4-methylbenzoate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics