Carbon-carbon bond construction at the 2-position of polysubstituted pyrimidinones was written by Zhang, Dawei;Sham, Kelvin;Cao, Guo-Qiang;Hungate, Randall;Dominguez, Celia. And the article was included in Tetrahedron Letters in 2002.Application In Synthesis of Ethyl 2-(4-fluorophenyl)acetate This article mentions the following:
A novel synthetic method to introduce a carbon-carbon bond at the 2-position of pyrimidinones via nucleophilic addition of Grignard reagents to 2-cyano pyrimidinones at ambient conditions is disclosed. This unique approach leads to the preparation of such biol. important mols. as polysubstituted pyrimidinones in good to excellent yields. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Application In Synthesis of Ethyl 2-(4-fluorophenyl)acetate).
Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application In Synthesis of Ethyl 2-(4-fluorophenyl)acetate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics