Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists was written by De Lucca, George V.;Kim, Ui T.;Johnson, Curt;Vargo, Brian J.;Welch, Patricia K.;Covington, Maryanne;Davies, Paul;Solomon, Kimberly A.;Newton, Robert C.;Trainor, George L.;Decicco, Carl P.;Ko, Soo S.. And the article was included in Journal of Medicinal Chemistry in 2002.Name: 3-Cyanophenylisocyanate This article mentions the following:
Structure-activity relationship (SAR) studies of initial screening hits from our corporate library of compounds and a structurally related series of CCR1 receptor antagonists were used to determine that an N-(alkyl)benzylpiperidine is an essential pharmacophore for selective CCR3 antagonists. Further SAR studies that introduced N-(ureidoalkyl) substituents improved the binding potency of these compounds from the micromolar to the low nanomolar range. This new series of compounds also displays highly potent, in vitro functional CCR3-mediated antagonism of eotaxin-induced Ca2+ mobilization and chemotaxis of human eosinophils. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Name: 3-Cyanophenylisocyanate).
3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Name: 3-Cyanophenylisocyanate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics