Valorization of perillaldehyde molecule contained in the essential oil of Ammodaucus leucotrichus Coss. from the Saharan zones of Morocco was written by Bouzekri, Omayma;El Gamouz, Sabah;Ghaleb, Adib;Amechrouq, Ali;El Idrissi, Mostafa;Choukrad, M’barek. And the article was included in Journal of Microbiology, Biotechnology and Food Sciences in 2022.Reference of 706-14-9 This article mentions the following:
The aim of this work is to valorise the species Ammodaucus leucotrichus Coss which is known by its abundance in perillaldehyde. The plant material was collected from two regions in Morocco: Errachidia and Smara region, then was hydrodistd. The essential oils (EOs) obtained were firstly characterized by gas chromatog. coupled to mass spectrometry (GC-MS). Secondly the EO with the major component is the perillaldehyde was used as starting material to semi-synthesize three p-menthane monoterpenoids. The semi-synthesized compounds from perillaldehyde were studied for their docking behavior against Lung Cancer with the crystallog. structure of the kinase domain of EGFR protein using surflex-docking. The GC/MS anal. of essential oils, showed a total of 25 components accounts 99.51% for Errachidia′s EO while 28 components account for 99.83% for Smara′s EO. GC/MS anal. showed that perillaldehyde is the major components in the EO of Errachidia with a percentage of 74.71%. For this purpose, Errachidia′s EO was used to semi-synthesize the perilla alc., the perillic acid, and the perillartine. The three compounds were obtained in good yield, their structures were confirmed by GC/MS and IR (IR). The mol. docking study showed a good binding affinity between the perilla alc. (POH) and the lung cancer receptor than perillic acid and perillartine. The species Ammodaucus leucotrichus Coss. could be considered a promising source of p-menthan monoterpenoids, known for their anticancerous properties. In the experiment, the researchers used many compounds, for example, 5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9Reference of 706-14-9).
5-Hexyldihydrofuran-2(3H)-one (cas: 706-14-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Reference of 706-14-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics