Suto, Mark J. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 1996 | CAS: 87694-53-9

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Formula: C16H24N2O4

Peptide inhibitors of IκB protease: modification of the C-termini of Z-LLF-CHO was written by Suto, Mark J.;Sullivan, Robert W.;Ransone, Lynn J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1996.Formula: C16H24N2O4 This article mentions the following:

A series of tripeptides (Z-Leu-Leu-Phe-R; where R is a modified C-terminus) were synthesized and evaluated for their ability to prevent the activation of NF-κB (nuclear factor κB) through the inhibition of IκB protease. Of the compounds evaluated, only the C-terminal aldehydes, Z-Leu-Leu-Phe-CHO and Z-Leu-Leu-D-Phe-CHO, were active in the Jurkat T-cell based assay. Z-Leu-Leu-Phe-CHO also decreased IL-2 and IL-8 levels in these cells indicating that inhibitors of IκB protease can have an effect on various signaling pathways. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Formula: C16H24N2O4).

(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Formula: C16H24N2O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics