Gold-Catalyzed Hydrofluorination of Internal Alkynes Using Aqueous HF was written by Gauthier, Raphael;Mamone, Marius;Paquin, Jean-Francois. And the article was included in Organic Letters in 2019.COA of Formula: C10H14O4 This article mentions the following:
The gold-catalyzed hydrofluorination reaction of internal alkynes using hydrofluoric acid is reported. Notably, these conditions use one of the most economical sources of HF and are free of addnl. additives. Both sym. and unsym. internal alkynes can be utilized, and the use of alkynes bearing a fluorinated group at the propargylic position as substrates allowed for a regioselective hydrofluorination reaction. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9COA of Formula: C10H14O4).
Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.COA of Formula: C10H14O4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics