Remote Cooperative Group Strategy Enables Ligands for Accelerative Asymmetric Gold Catalysis was written by Wang, Zhixun;Nicolini, Corrado;Hervieu, Cedric;Wong, Yuk-Fai;Zanoni, Giuseppe;Zhang, Liming. And the article was included in Journal of the American Chemical Society in 2017.Quality Control of Diethyl 2-(prop-2-yn-1-yl)malonate This article mentions the following:
An accelerative asym. gold catalysis is achieved for the first time via chiral ligand metal cooperation. An asym. positioned remote amide group in the designed chiral binaphthyl-based ligand plays the essential role of a general base catalyst and selectively accelerates the cyclizations of 4-allen-1-ols into one prochiral allene face. The reactions are mostly highly enantioselective with achiral substrates, and due to the accelerated nature of the catalysis catalyst loadings as low as 100 ppm are allowed. With a pre-existing chiral center at any of the backbone sp3-carbons, the reaction remained highly efficient and most importantly maintained excellent allene facial selectivities regardless of the substrate stereochem. By using different combinations of ligand and substrate enantiomers, it is now possible to access all four stereoisomers of versatile 2-vinyltetrahydrofurans with exceedingly high selectivity. The underpinning design of this chem. reveals a novel and conceptually distinctive strategy to tackle challenging asym. gold catalysis, which to date has relied on decelerative asym. steric hindrance approaches. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Quality Control of Diethyl 2-(prop-2-yn-1-yl)malonate).
Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Quality Control of Diethyl 2-(prop-2-yn-1-yl)malonate
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