Cross-Coupling between Difluorocarbene and Carbene-Derived Intermediates Generated from Diazocompounds for the Synthesis of gem-Difluoroolefins was written by Zheng, Jian;Lin, Jin-Hong;Yu, Liu-Ying;Wei, Yun;Zheng, Xing;Xiao, Ji-Chang. And the article was included in Organic Letters in 2015.Application In Synthesis of Ethyl 2-fluorophenylacetate This article mentions the following:
Cross-coupling between difluorocarbene and carbene-derived intermediates generated from diazo compounds was developed to give gem-difluoroolefins, which constitutes a fast practical pathway to achieve hindered gem-difluoroolefins. The cross-coupling between difluorocarbene and aryl diazoacetates proceeded smoothly in the presence of a copper source, whereas its coupling with diaryl diazomethanes occurred well under metal-free conditions. A mechanism involving a copper-difluorocarbene complex was proposed. In the experiment, the researchers used many compounds, for example, Ethyl 2-fluorophenylacetate (cas: 584-74-7Application In Synthesis of Ethyl 2-fluorophenylacetate).
Ethyl 2-fluorophenylacetate (cas: 584-74-7) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application In Synthesis of Ethyl 2-fluorophenylacetate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics