Small Molecule Suppression of Carbapenem Resistance in NDM-1 Producing Klebsiella pneumoniae was written by Worthington, Roberta J.;Bunders, Cynthia A.;Reed, Catherine S.;Melander, Christian. And the article was included in ACS Medicinal Chemistry Letters in 2012.Reference of 87694-53-9 This article mentions the following:
The already considerable global public health threat of multidrug-resistant Gram-neg. bacteria has become even more of a concern following the emergence of New Delhi metallo-β-lactamase (NDM-1) producing strains of Klebsiella pneumoniae and other Gram-neg. bacteria. As an alternative approach to the traditional development of new bactericidal entities, we have identified a 2-aminoimidazole-derived small mol. that acts as an antibiotic adjuvant and is able to suppress resistance of a NDM-1 producing strain of K. pneumoniae to imipenem and meropenem, in addition to suppressing resistance of other β-lactam nonsusceptible K. pneumoniae strains. The small mol. is able to lower carbapenem min. inhibitory concentrations by up to 16-fold, while exhibiting little bactericidal activity itself. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Reference of 87694-53-9).
(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Reference of 87694-53-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics