Optically active γ-hydroxy sulfone Julia reagents for the synthesis of peptidyl olefin peptidomimetics was written by Mirilashvili, Sima;Chasid-Rubinstein, Naama;Albeck, Amnon. And the article was included in European Journal of Organic Chemistry in 2008.Recommanded Product: 10203-58-4 This article mentions the following:
Peptidyl olefin peptidomimetics serve as biol. active compounds or as intermediates for other peptidyl isosteres. We developed a chemoenzymic stereoselective approach to optically active γ-hydroxy sulfones to be assembled into peptidyl olefins by the Julia reaction. Key enzymic hydrolysis of prochiral diesters to the corresponding hydroxy esters introduces optical activity. The sequence of the subsequent chem. reactions, either protection-hydrolysis-functionalization or functionalization-hydrolysis-protection, determines the absolute stereochem. of the final sulfone building block. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Recommanded Product: 10203-58-4).
Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 10203-58-4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics