An efficient conversion of carboxylic acids into Weinreb amides was written by Katritzky, Alan R.;Yang, Hongfang;Zhang, Suoming;Wang, Mingyi. And the article was included in ARKIVOC (Gainesville, FL, United States) [online computer file] in 2002.Quality Control of (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate This article mentions the following:
Efficient conversions of carboxylic acids into Weinreb amides were achieved by treatment of N-acylbenzotriazoles 2a-i with N,O-dimethylhydroxylamine hydrochloride under mild conditions. No racemization was found when optically active acids were employed. In the experiment, the researchers used many compounds, for example, (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9Quality Control of (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate).
(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (cas: 87694-53-9) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Quality Control of (S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics