Palladium-catalyzed arylation of diisopropyl malonate applied to the efficient synthesis of the selective MMP inhibitor 5-(4-phenoxyphenyl)-5-[4-(2-pyrimidinyl)-1-piperazinyl]barbituric acid was written by Hutchings, Stanley;Liu, Wen;Radinov, Roumen. And the article was included in Heterocycles in 2006.Electric Literature of C11H20O4 This article mentions the following:
An efficient synthesis of the highly selective MMP inhibitor 5-(4-phenoxyphenyl)-5-(4-pyrimidin-2-ylpiperazin-1-yl)barbituric acid is reported. The title compound was prepared in three steps and 72% overall yield from 4-bromophenyl Ph ether via an improved arylation of diisopropyl malonate. In the experiment, the researchers used many compounds, for example, malonic acid dibutyl ester (cas: 1190-39-2Electric Literature of C11H20O4).
malonic acid dibutyl ester (cas: 1190-39-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Electric Literature of C11H20O4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics