Disparities in chemical exposures among pregnant women and neonates by socioeconomic and demographic characteristics: A nontargeted approach was written by Goin, Dana E.;Abrahamsson, Dimitri;Wang, Miaomiao;Jiang, Ting;Park, June-Soo;Sirota, Marina;Morello-Frosch, Rachel;DeMicco, Erin;Zlatnik, Marya G.;Woodruff, Tracey J.. And the article was included in Environmental Research in 2022.Computed Properties of C20H26O4 This article mentions the following:
Exposure to environmental chems. during pregnancy adversely affects maternal and infant health, and identifying socio-demog. differences in exposures can inform contributions to health inequities. We recruited 294 demog. diverse pregnant participants in San Francisco from the Mission Bay/Moffit Long (MB/ML) hospitals, which serve a primarily higher income population, and Zuckerberg San Francisco General Hospital (ZSFGH), which serves a lower income population. We collected maternal and cord sera, which we screened for 2420 unique formulas and their isomers using high-resolution mass spectrometry using LC-QTOF/MS. We assessed differences in chem. abundances across socioeconomic and demog. groups using linear regression adjusting for false discovery rate. Our participants were racially diverse (31% Latinx, 16% Asian/Pacific Islander, 5% Black, 5% other or multi-race, and 43% white). A substantial portion experienced financial strain (28%) and food insecurity (20%) during pregnancy. We observed significant abundance differences in maternal (9 chems.) and cord sera (39 chems.) between participants who delivered at the MB/ML hospitals vs. ZSFGH. Of the 39 chem. features differentially detected in cord blood, 18 were present in pesticides, one per- or poly-fluoroalkyl substance (PFAS), 21 in plasticizers, 24 in cosmetics, and 17 in pharmaceuticals; 4 chem. features had unknown sources. A chem. feature annotated as 2,4-dichlorophenol had higher abundances among Latinx compared to white participants, those delivering at ZSFGH compared to MB/ML, those with food insecurity, and those with financial strain. Post-hoc QTOF analyses indicated the chem. feature was either 2,4-dichlorophenol or 2,5-dichlorophenol, both of which have potential endocrine-disrupting effects. Chem. exposures differed between delivery hospitals, likely due to underlying social conditions faced by populations served. Differential exposures to 2,4-dichlorophenol or 2,5-dichlorophenol may contribute to disparities in adverse outcomes. In the experiment, the researchers used many compounds, for example, Dicyclohexyl phthalate (cas: 84-61-7Computed Properties of C20H26O4).
Dicyclohexyl phthalate (cas: 84-61-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Computed Properties of C20H26O4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics