Compounds with antineoplastic activity. LXXXII. 5,5-Disubstituted barbituric acids and their analogs was written by Kotva, Rudolf;Krepelka, Jiri;Semonsky, Miroslav. And the article was included in Collection of Czechoslovak Chemical Communications in 1983.Recommanded Product: 17920-23-9 This article mentions the following:
Barbituric acid derivatives I [R = Me, Et, Pr, Bu, Ph, CH2:CHCH2, R1 = (CH2)4CO2H; R = Et, Bu, R1 = (CH2)4CONHCH2CO2Et], II (R = Me, Pr), and III [R = CH2:CHCH2, (CH2)4CO2H, R1 = (CH2)4CO2H; R = HCCCH2, (CH2)4CO2Et] were prepared by cyclocondensation of (EtO2C)2CR(CH2)4CO2Et with urea, thiourea, and guanidine. Compound III [R = CH2:CHCH2, R1 = (CH2)4CO2H] enhanced the action of 5-fluorouracil on leukemia in mice by 22% at a dose at 200 mg/kg. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Recommanded Product: 17920-23-9).
Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 17920-23-9
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics