Mild halogenation of stabilized ester enolates by cupric halides was written by Shi, Xiaoxin;Dai, Lixin. And the article was included in Journal of Organic Chemistry in 1993.Recommanded Product: Diethyl 2-(prop-2-yn-1-yl)malonate This article mentions the following:
The reactions of various stabilized ester enolates of 2-keto, 2-(alkoxycarbonyl), 2-phosphoryl, and 2-(benzenesulfonyl) esters with cupric chloride or cupric bromide have been examined The reactions lead to 2-halo esters in good to excellent yields under mild conditions. Enolates which contain an unsaturated functionality such as a double bond, a triple bond, or an allylic or a benzylic moiety react with high chemoselectivity. In the experiment, the researchers used many compounds, for example, Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9Recommanded Product: Diethyl 2-(prop-2-yn-1-yl)malonate).
Diethyl 2-(prop-2-yn-1-yl)malonate (cas: 17920-23-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: Diethyl 2-(prop-2-yn-1-yl)malonate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics