Controlled Relay Process to Access N-Centered Radicals for Catalyst-free Amidation of Aldehydes under Visible Light was written by Lee, Wongyu;Jeon, Hyun Ji;Jung, Hoimin;Kim, Dongwook;Seo, Sangwon;Chang, Sukbok. And the article was included in Chem in 2021.Safety of 4-Formyl-2-methoxyphenyl isobutyrate This article mentions the following:
Here, a new relay process involving the slow in situ generation of a photoactive N-chloro species via C-N bond formation, which subsequently enables mild and selective access to N-centered radicals under visible light conditions was reported. The utility of this approach was demonstrated by the conversion of aldehydes to amides I [R1 = t-Bu, cyclopropyl, Ph, etc.; R2 = Boc, Cbz, Ts, etc.], employing N-chloro-N-sodio carbamates as a practical amidating source. This synthetic operation obviated the need for catalysts, external oxidants, and coupling reagents that were typically required in related processes, consequently allowed high functional group tolerance and excellent applicability for late-stage functionalization. In the experiment, the researchers used many compounds, for example, 4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4Safety of 4-Formyl-2-methoxyphenyl isobutyrate).
4-Formyl-2-methoxyphenyl isobutyrate (cas: 20665-85-4) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Safety of 4-Formyl-2-methoxyphenyl isobutyrate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics