Synthesis of bridgehead-substituted bicyclo[2.2.1]heptanes by radical cyclization was written by Della, Ernest W.;Knill, Andrew M.;Pigou, Paul E.. And the article was included in Journal of Organic Chemistry in 1993.Computed Properties of C10H16O2 This article mentions the following:
A kinetic investigation shows that the rate of cyclization (kC) of the (4-methylenecyclohexyl)methyl radical (I) at 25° is 4.4 × 102 s-1, considerably slower than that (2.3 × 105 s-1) of the parent 5-hexenyl radical. The activation energy for the cyclization is 12.8 kcal mol-1, which is in excellent agreement with theor. values derived from force-field calculations Ring closure of appropriately substituted (4-methylenecyclohexyl)methyl radical precursors allows the synthesis of bicyclo[2.2.1]heptyl systems with useful functionality at the bridgehead to be achieved readily and in high yield. An interesting example is given of the application of an iodine-atom-transfer cyclization to the synthesis of a bicyclo[2.2.1]heptane functionalized at C-7 and C-1. In the experiment, the researchers used many compounds, for example, Ethyl 4-methylenecyclohexanecarboxylate (cas: 145576-28-9Computed Properties of C10H16O2).
Ethyl 4-methylenecyclohexanecarboxylate (cas: 145576-28-9) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Computed Properties of C10H16O2
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics