Pen G acylase catalyzed resolution of phenylacetate esters of secondary alcohols was written by Baldaro, E.;D’Arrigo, P.;Pedrocchi-Fantoni, G.;Rosell, C. M.;Servi, S.;Tagliani, A.;Terreni, M.. And the article was included in Tetrahedron: Asymmetry in 1993.Synthetic Route of C11H14O3 This article mentions the following:
Penicillin G acylase from E. coli (Pen G acylase) (EC 3.5.1.11) immobilized on Eupergit C is used for the kinetic resolution of phenylacetate esters of secondary alcs. of pharmaceutical interest. Thus, treatment of racemic esters (RS)-PhCH2CO2CHRR1 (R = Me, Et, CH:CH2, CH2Ph, CO2Et, CO2Me, CH2CH2Cl, CH2CO2Et; R1 = Me, Ph, CH2CH2Ph) gave chiral alcs. I in 10 to >98% enantiomeric excess. In the experiment, the researchers used many compounds, for example, Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0Synthetic Route of C11H14O3).
Ethyl 2-hydroxy-3-phenylpropanoate (cas: 15399-05-0) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Synthetic Route of C11H14O3
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics