Zimra, Yael published the artcileButyric acid and pivaloyloxymethyl butyrate, AN-9, a novel butyric acid derivative, induce apoptosis in HL-60 cells, Formula: C10H18O4, the publication is Journal of Cancer Research and Clinical Oncology (1997), 123(3), 152-160, database is CAplus and MEDLINE.
It is shown that AN-9 and butyrate induce cell death by apoptosis. Exposure of HL-60 cells to butyrate and AN-9 decreased cell numbers and induced cell differentiation and the appearance of typical apoptotic features. Induction of apoptosis and/or differentiation was dependent on the concentration and the time of exposure to the drugs. The advantage of An-9 over butyrate was further confirmed. AN-9-induced apoptosis occurred after a shorter exposure and at lower drug concentrations than that induced by butyrate. Apoptosis by AN-9 was accompanied by reduction in Bcl-2 expression. Preincubation with antioxidants did not protect HL-60 cells from apoptosis induced by AN-9.
Journal of Cancer Research and Clinical Oncology published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C19H36BNO2Si, Formula: C10H18O4.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics