Zhang, Jing published the artcileDesign, Synthesis, and Structure-Activity Relationship Study of Pyrazolones as Potent Inhibitors of Pancreatic Lipase, Product Details of C6H10O3, the publication is ChemMedChem (2021), 16(10), 1600-1604, database is CAplus and MEDLINE.
In this study, a series of pyrazolones was synthesized, and their inhibitory effects against pancreatic lipase (PL) were assayed by using 4-methylumbelliferyl oleate (4-MUO) as optical substrate for PL. Comprehensive structure-activity relationship anal. of these pyrazolones led us to design and synthesize a novel compound I as a potent mixed-competitive inhibitor of PL (IC50=0.30μM). In addition, compound I displayed some selectivity over other known serine hydrolases. A mol. docking study for compound I demonstrated that the inhibitory activity of compound I towards PL could be attributed to the π-π interactions of 2-naphthyl unit and hydrophobic interactions of Ph moiety with the active site of PL. Thus, compound I could serve as promising lead compound for the development of more efficacious and selective pyrazolones-type PL inhibitors for biomedical applications.
ChemMedChem published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C11H21BF4N2O2, Product Details of C6H10O3.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics