Wang, Xiao-Mei published the artcileEnantioselective Synthesis of Nitrogen-Nitrogen Biaryl Atropisomers via Copper-Catalyzed Friedel-Crafts Alkylation Reaction, Name: Methyl 3-oxovalerate, the publication is Journal of the American Chemical Society (2021), 143(37), 15005-15010, database is CAplus and MEDLINE.
Nitrogen-nitrogen bonds containing motifs are ubiquitous in natural products and bioactive compounds However, the atropisomerism arising from a restricted rotation around an N-N bond is largely overlooked. Here, a method to access the first enantioselective synthesis of N-N biaryl atropisomers via a Cu-bisoxazoline-catalyzed Friedel-Crafts alkylation reaction is described. A wide range of axially chiral N-N bisazaheterocycle compounds were efficiently prepared in high yields with excellent enantioselectivities via desymmetrization and kinetic resolution Heating experiments showed that the axially chiral bisazaheterocycle products have high rotational barriers.
Journal of the American Chemical Society published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C13H9FO, Name: Methyl 3-oxovalerate.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics