Wang, Jiu published the artcileTechnical improvement for synthesis of levofloxacin, Safety of Ethyl 3-(dimethylamino)acrylate, the publication is Guangzhou Huagong (2012), 40(9), 118-120, database is CAplus.
The levofloxacin process was optimized. Levofloxacin was prepared with 2,3,4,5-tetrafluorobenzoyl chloride as the starting material, by acylation, amination, and cyclization left oxyfluoride cyclization ester was obtained, and then Piperazine and left oxyfluoride cyclization ester condensation, after methylation by di-Me sulfate, hydrolysis, condensation. Comparing to the old process, Piperazine instead of N-methylpiperazine, process was improved with many advantages, such as improving the yield and quality of the product, reducing the cost, reducing environmental pollution, and tech. indicators in line with the CP2010 Levofloxacin requirements.
Guangzhou Huagong published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C13H11NO, Safety of Ethyl 3-(dimethylamino)acrylate.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics