Ma, Shuai published the artcileSynthesis of elvitegravir, SDS of cas: 924-99-2, the publication is Zhongguo Yiyao Gongye Zazhi (2014), 45(1), 5-8, database is CAplus.
Elvitegravir was synthesized from 2,4-difluorobenzoic acid via iodization, acylation and condensation to give Et 2-(2,4-difluoro-5-iodobenzoyl)-3-dimethylaminoacrylate, which was subjected to addition-elimination with L-valinol, cyclization, protection with tert-butyldimethylsilyl chloride and Negishi coupling reaction with 3-chloro-2-fluorobenzylzinc bromide, followed by one-pot synthesis including deprotection, hydrolysis and methoxylation with an overall yield of about 42%.
Zhongguo Yiyao Gongye Zazhi published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, SDS of cas: 924-99-2.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics