Liu, Xigong published the artcileConstruction of Vicinal Quaternary Carbon Stereocenters Through Diastereo- and Enantioselective Oxidative 1,6-Conjugate Addition, SDS of cas: 517-23-7, the publication is Angewandte Chemie, International Edition (2021), 60(34), 18499-18503, database is CAplus and MEDLINE.
The asym. construction of vicinal quaternary carbon stereocenters with at least one moiety in acyclic systems is a formidable challenge. A solution involving diastereo- and enantioselective oxidative 1,6-conjugate addn was disclosed. The practical asym. cross-dehydrogenative coupling of 2,2-diarylacetonitriles and diverse α-substituted cyclic 1,3-dicarbonyls proceeds, for vicinal quaternary carbon stereocenters with one center in acyclic systems, in excellent yields and stereoselectivities. The generality of the approach was further demonstrated by the stereoselective creation of vicinal quaternary carbon stereocenters with both centers in acyclic systems using acyclic β-ketoesters as coupling partners. Computational studies elucidate the origins of both diastereo- and enantioselectivity.
Angewandte Chemie, International Edition published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, SDS of cas: 517-23-7.
Referemce:
https://en.wikipedia.org/wiki/Ester,
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