Al-Qawasmeh, Raed A. published the artcileSynthesis and antibacterial activity of 9-cyclopropyl-4-fluoro-6-oxo-6,9-dihydro-[1,2,5]thiadiazolo[3,4-h]quinoline-7-carboxylic acid and its ethyl ester, Safety of Ethyl 3-(dimethylamino)acrylate, the publication is ARKIVOC (Gainesville, FL, United States) (2009), 322-336, database is CAplus.
Synthesis and the antimicrobial activity of 9-cyclopropyl-4-fluoro-6-oxo[1,2,5]thiadiazolo[3,4-h]quinoline-5-carboxylic acid (I) and Et ester are reported. Compound I was prepared in good yield via thermal cyclocondensation of Et 7,8-diamino-9-cyclopropyl-4-fluoro-6-oxoquinoxaline-7-carboxylate with thionyl chloride, followed by acid-catalyzed hydrolysis. The structures of all synthesized compounds were characterized by IR, MS, 1H- and 13C NMR spectra; the structure of compound I was confirmed by X-ray crystal structure anal. The antibacterial and antifungal evaluation against a broad panel of wild and resistant Gram-pos. and Gram-neg. bacteria and fungal species demonstrated the high antibacterial activity of compound I, even at the concentration of 0.015 μg mL-1.
ARKIVOC (Gainesville, FL, United States) published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Safety of Ethyl 3-(dimethylamino)acrylate.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics