Gardiner, James published the artcileβ-peptide conjugates: Syntheses and CD and NMR investigations of β/α-chimeric peptides, of a DPA-β-decapeptide, and of a PEGylated β-heptapeptide, Related Products of esters-buliding-blocks, the main research area is chimeric peptide dipicolinic acid solid phase synthesis; PEGylated heptapeptide solid phase synthesis; peptide solution mol structure CD NMR helical conformation.
β3-Peptides consisting of six, seven, and ten homologated proteinogenic amino acid residues have been attached to an α-heptapeptide (all D-amino acid residues), to a hexaethylene glycol chain (PEGylation), and to dipicolinic acid (DPA derivative, DPA = dipicolinic acid), resp. The conjugation of the β-peptides with the second component was carried out through the N-termini in all three cases. According to NMR anal. (CD3OH solutions), the (M)-314-helical structure of the β-peptidic segments was unscathed in all three chimeric compounds The α-peptidic section of the α/β-peptide was unstructured, and so was the oligoethylene glycol chain in the PEGylated compound Thus, neither does the appendage influence the β-peptidic secondary structure, nor does the latter cause any order in the attached oligomers to be observed by this method of anal. A similar conclusion may be drawn from CD spectra. These results bode well for the development of delivery systems involving β-peptides.
Helvetica Chimica Acta published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 882847-32-7 belongs to class esters-buliding-blocks, name is 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azadocosan-22-oic acid, and the molecular formula is C28H37NO9, Related Products of esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics