Donabauer, Karsten published the artcilePhotocatalytic Reductive Radical-Polar Crossover for a Base-Free Corey-Seebach Reaction, Product Details of C7H12O3, the main research area is hydroxymethyl dithiane preparation; dithiane photocatalytic Corey Seebach aldehyde ketone; Corey-Seebach; HAT-catalysis; carbanion; photocatalysis; radical-polar crossover.
A photocatalytic approach to the Corey-Seebach reaction has been described. The presented method operates under mild redox-neutral and base-free conditions giving the desired product with high functional group tolerance. The reaction is enabled by the combination of photo- and hydrogen atom transfer (HAT) catalysis. This catalytic merger allows a C-H to carbanion activation by the abstraction of a hydrogen atom followed by radical reduction The generated nucleophilic intermediate is then capable of adding to carbonyl electrophiles. By this approach, dithianes I (R1 = Me, NCCH2CH2, PhCH2CH2, etc.) were reacted with various aldehydes and ketones R2C(O)R3 [R2 = Et, i-Pr, MeSCH2CH2, R3 = H; R2 = n-Pr, i-Pr, PhCH2CH2, etc., R3 = Me; R2R3 = (CH2)3, (CH2)2O(CH2)2, etc.] giving access to the valuable α-hydroxy dithianes II. The proposed reaction mechanism is supported by emission quenching, radical-radical homocoupling and deuterium labeling studies as well as by calculated redox-potentials and bond strengths.
Chemistry – A European Journal published new progress about Aliphatic aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 539-88-8 belongs to class esters-buliding-blocks, name is Ethyl 4-oxopentanoate, and the molecular formula is C7H12O3, Product Details of C7H12O3.
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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics