Zhu, Yun-fei published the artcileSynthesis of 5-amino-1-cyclopropyl-7-[3,5-dimethyl-1-piperazinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (sparfloxacin), COA of Formula: C7H13NO2, the publication is Zhongguo Xinyao Zazhi (2008), 17(9), 757-759, database is CAplus.
A method for the synthesis of the title compound [i.e., 5-amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, fluoroquinolone antibacterial agent] is reported here. Said compound was prepared from 2,3,4,5-tetrafluorobenzoic acid via nitration and acyl chlorination before coupling with Et (dimethylamino)acrylate, cyclopropylamine displacement, cyclization, reduction, hydrolysis and condensation with 2,6-dimethylpiperazine. The overall yield was 34.2%. Compared to a known process, this synthetic sequence eliminates three reaction steps; di-Et malonate condensation, partial hydrolysis decarboxylation and tri-Et orthoformate condensation. Said process has advantages, such as short reaction time, mild reaction conditions, waste reduction, yield increase, and a good prospect for industrial application.
Zhongguo Xinyao Zazhi published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C5H10N2OS, COA of Formula: C7H13NO2.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics