Ulriksdotter, J. published the artcileAllergic contact dermatitis caused by dipropylene glycol diacrylate in the Omnipod insulin pump, Application of Trimethylolpropane triacrylate, the publication is British Journal of Dermatology (2022), 186(2), 334-340, database is CAplus and MEDLINE.
Cases of allergic contact dermatitis (ACD) caused by isobornyl acrylate (IBOA) in the Omnipod insulin pump have previously been reported. To present three cases of patients with ACD caused by a new allergen in the pump, and results from chem. analyses. Omnipod pumps from different batches were analyzed by gas chromatog.-mass spectrometry. Aimed testing, with the department’s medical device (MD) series and substances identified in the pump including dipropylene glycol diacrylate (DPGDA) at 0·01% and 0·1% in petrolatum (pet.), was performed. Patch testing also included extracts from the device, the adhesive patch as is, and allergens from baseline series. All patients tested pos. to 0·1% DPGDA in pet., and two patients addnl. to a 0·01% concentration DPGDA was found in extracts of the Omnipod pumps brought by the patients. An Omnipod pump from an earlier batch contained tripropylene glycol diacrylate, IBOA, N,N-dimethylacrylamide, di(ethylene glycol)ethyl ether acrylate (DEGEA) but no DPGDA. One of the patients reacted pos. to all of these allergens except DEGEA, which was not tested. When suspecting ACD to MDs, DPGDA at 0·1% in pet. should be tested. The contents of Omnipod have changed over time. Patch testing with updated test series and relevance assessment of pos. reactions is a delicate task. Children, with lifelong use of MDs, risk contracting many allergies with potential cross-allergies. A question should be raised as to whether these low mol. weight acrylates should be used at all in devices constantly worn on the skin.
British Journal of Dermatology published new progress about 15625-89-5. 15625-89-5 belongs to esters-buliding-blocks, auxiliary class Polymerization Reagents,Crosslinkers, name is Trimethylolpropane triacrylate, and the molecular formula is C10H18O, Application of Trimethylolpropane triacrylate.
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