Shin, Junhwa published the artcileAn Efficient New Route to Plasmenyl-type Lipids: Synthesis and Cytotoxicity of a Plasmenylcholine Analog of the Antitumor Ether Lipid ET-18-OMe, COA of Formula: C9H9NO6S, the publication is Journal of the American Chemical Society (2001), 123(3), 508-509, database is CAplus and MEDLINE.
Glycerolipid I has been prepared via a facile reaction sequence with use of an acrolein acetal derivative and 1-iodo-tridecane as precursors under Barbier-type reaction conditions. The observed regioselectivities and high Z:E ratios of the lithiated 4,4-di-tert-butylbiphenyl (DBB)-mediated coupling reaction are likely due to a lithiated allylic anion that undergoes stereoselective γ-coupling with electrophiles via lithium ion-acetal chelation. The resulting racemic I shows cytotoxic properties similar to the clin. relevant ATL analog 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OMe); however, it is not presently known whether the cytotoxic mechanism for I is apoptotic in nature as it is for ET-18-OMe. Experiments designed to adapt this method for the preparation of plasmalogens and the pure R-I/S-I stereoisomers are in progress. Addnl. experiments aimed at probing the relative cytotoxicity of R-I, S-I, and racemic I, as well as the mechanism of cell death upon exposure to these ATL, are also planned.
Journal of the American Chemical Society published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C7H3Cl2F3O2S, COA of Formula: C9H9NO6S.
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https://en.wikipedia.org/wiki/Ester,
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