Robinson, Emma J.’s team published research in Metabolites in 11 | CAS: 30414-53-0

Metabolites published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Formula: C6H10O3.

Robinson, Emma J. published the artcileAqueous Metabolite Trends for the Progression of Nonalcoholic Fatty Liver Disease in Female Bariatric Surgery Patients by Targeted 1H-NMR Metabolomics, Formula: C6H10O3, the publication is Metabolites (2021), 11(11), 737, database is CAplus and MEDLINE.

Determining biomarkers and better characterizing the biochem. progression of nonalcoholic fatty liver disease (NAFLD) remains a clin. challenge. A targeted 1H-NMR study of serum, combined with clin. variables, detected and localized biomarkers to stages of NAFLD in morbidly obese females. Pre-surgery serum samples from 100 middle-aged, morbidly obese female subjects, grouped on gold-standard liver wedge biopsies (non-NAFLD; steatosis; and fibrosis) were collected, extracted, and analyzed in aqueous (D2O) buffer (1H, 600 MHz). Profiled concentrations were subjected to exploratory statistical anal. Metabolites varying significantly between the non-NAFLD and steatosis groups included the ketone bodies 3-hydroxybutyrate (� p = 0.035) and acetone (� p = 0.012), and also alanine (� p = 0.004) and a putative pyruvate signal (� p = 0.003). In contrast, the steatosis and fibrosis groups were characterized by 2-hydroxyisovalerate (� p = 0.023), betaine (� p = 0.008), hypoxanthine (� p = 0.003), taurine (� p = 0.001), 2-hydroxybutyrate (� p = 0.045), 3-hydroxyisobutyrate (� p = 0.046), and increasing medium chain fatty acids. Exploratory classification models with and without clin. variables exhibited overall success rates ca. 75-85%. In the study conditions, inhibition of fatty acid oxidation and disruption of the hepatic urea cycle are supported as early features of NAFLD that continue in fibrosis. In fibrosis, markers support inflammation, hepatocyte damage, and decreased liver function. Complementarity of NMR concentrations and clin. information in classification models is shown. A broader hypothesis that standard-of-care sera can yield metabolomic information is supported.

Metabolites published new progress about 30414-53-0. 30414-53-0 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ketone,Ester, name is Methyl 3-oxovalerate, and the molecular formula is C6H10O3, Formula: C6H10O3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics