Ram, Ram N. published the artcileβ,β,β-Trichloroethyl-NH-Enamine as Viable System for 5-Endo-trig Radical Cyclization via Multifaceted CuI-CuII Redox Catalysis: Single Step Synthesis of Multi-Functionalized NH-Pyrroles, Category: esters-buliding-blocks, the publication is Advanced Synthesis & Catalysis (2019), 361(24), 5661-5676, database is CAplus.
A mild and regioselective copper-catalyzed direct synthesis of multi-substituted and functionalized NH-pyrroles was reported in high yields from diverse β,β,β-trichloroethyl-NH-enamines via a novel 5-endo-trig radical cyclization mode, previously known to be unviable in the enamine system. An approach to transform a geometrically ‘disfavored to favored’ 5-endo-trig radical cyclization mode in NH-enamine systems via multifaceted CuI-CuII redox catalysis generating radicals, preventing dehalogenative reduction of radical precursors and dehydrohalogenating the 5-endo-trig cyclized products was demonstrated exptl. With wider substrate scope, this method incorporated halo-, NH- and carbonyl functionalities besides alkyl, aryl and heteroaryl substituents in the pyrrole unit easily. These difficult 3-halo-NH-pyrroles are potential sources for natural products, agrochems., pharmaceuticals and organometallic chem.
Advanced Synthesis & Catalysis published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Category: esters-buliding-blocks.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics