Nudelman, Abraham published the artcileNovel anticancer prodrugs of butyric acid. 2, Computed Properties of 122110-53-6, the publication is Journal of Medicinal Chemistry (1992), 35(4), 687-94, database is CAplus and MEDLINE.
The antitumor activity of novel prodrugs of butyric acid was examined The in vitro effect of the compounds on induction of cytodifferentiation and on inhibition of proliferation and clonogenicity showed that (pivaloyloxy)methyl butyrate (I) was the most active drug. Structure-activity relation study suggested that its activity stemmed from hydrolytically released butyric acid. In vivo, I displayed antitumor activity in B16F0 melanoma primary cancer model, manifested by a significant increase in the life span of the treated animals. Murine lung tumor burden, induced by injection of the highly metastatic melanoma cells (B16F10.9), was decrease byd I. It also displayed a significant therapeutic activity against spontaneous metastases which were induced by 3LL Lewis lung carcinoma cells. Moreover, I has the advantage of low toxicity, with an acute LD50 = 1.36 g/kg). I is a potential antineoplastic agent.
Journal of Medicinal Chemistry published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, Computed Properties of 122110-53-6.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics