Krushinski, Joseph H.’s team published research in Bioorganic & Medicinal Chemistry Letters in 17 | CAS: 115314-17-5

Bioorganic & Medicinal Chemistry Letters published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Application In Synthesis of 115314-17-5.

Krushinski, Joseph H. published the artcileIndoloxypropanolamine analogues as 5-HT1A receptor antagonists, Application In Synthesis of 115314-17-5, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(20), 5600-5604, database is CAplus and MEDLINE.

Analogs of pindolol, 1-(1H-indol-4-yloxy)-3-(isopropylamino)propan-2-ol, were synthesized and evaluated as 5-HT1A receptor antagonists. The structural features required for optimal binding to the 5-HT1A receptor are as follows: S-2-propanol linker, 4-indoloxy substituent, and a large lipophilic cyclic amine substituent. Compound I is a potent antagonist at the 5-HT1A receptor. This compoundis not a candidate for further development because of its affinity for the β1 and β2 receptors.

Bioorganic & Medicinal Chemistry Letters published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Application In Synthesis of 115314-17-5.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics