Koch, Bjoern E. V. published the artcileA quantitative in vivo assay for craniofacial developmental toxicity of histone deacetylases, Quality Control of 122110-53-6, the publication is Toxicology Letters (2021), 20-25, database is CAplus and MEDLINE.
Many bony features of the face develop from endochondral ossification of preexisting collagen-rich cartilage structures. The proper development of these cartilage structures is essential to the morphol. formation of the face. The developmental programs governing the formation of the pre-bone facial cartilages are sensitive to chem. compounds that disturb histone acetylation patterns and chromatin structure. We have taken advantage of this fact to develop a quant. morphol. assay of craniofacial developmental toxicity based on the distortion and deterioration of facial cartilage structures in zebrafish larvae upon exposure to increasing concentrations of several well-described histone deacetylase inhibitors. In this assay, we measure the angle formed by the developing ceratohyal bone as a precise, sensitive and quant. proxy for the overall developmental status of facial cartilages. Using the well-established developmental toxicant and histone deacetylase-inhibiting compound valproic acid along with 12 structurally related compounds, we demonstrate the applicability of the ceratohyal angle assay to investigate structure-activity relationships.
Toxicology Letters published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, Quality Control of 122110-53-6.
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https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics