Kasukabe, T. published the artcileAn anticancer derivative of butyric acid (pivalyloxymethyl butyrate) and daunorubicin cooperatively prolong survival of mice inoculated with monocytic leukemia cells, Synthetic Route of 122110-53-6, the publication is British Journal of Cancer (1997), 75(6), 850-854, database is CAplus and MEDLINE.
Pivalyloxymethyl butyrate (AN-9) inhibited the proliferation of and induced apoptosis in mouse monocytic leukemia Mm-A cells; Na butyrate, but not AN-9, induced differentiation of the cells. AN-9 and various DNA-specific antineoplastic agents synergistically inhibited the growth of Mm-A cells, and simultaneous treatment was required to evoke the maximum growth-inhibitory effect. On the other hand, there was no synergy between butyrate and these drugs, or between AN-9 and several antimetabolic agents, in inhibiting the growth of the cells, suggesting that the synergistic effect is specific to AN-9 and DNA-reacting agents. AN-9, given alone, dose-dependently prolonged the survival of mice inoculated with Mm-A cells. Moreover, administration of AN-9 plus daunorubicin (DNR) further prolonged survival.
British Journal of Cancer published new progress about 122110-53-6. 122110-53-6 belongs to esters-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Ester,Inhibitor, name is (Pivaloyloxy)methyl butyrate, and the molecular formula is C10H18O4, Synthetic Route of 122110-53-6.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics