Cecchetti, Violetta published the artcileStudies on 6-aminoquinolones: synthesis and antibacterial evaluation of 6-amino-8-ethyl- and 6-amino-8-methoxyquinolones, Computed Properties of 924-99-2, the publication is Bioorganic & Medicinal Chemistry (1999), 7(11), 2465-2471, database is CAplus and MEDLINE.
From our quant. structure-activity relationship (QSAR) study on a large set of 6-aminoquinolones, which indicated that a group larger than Me could be allocated at C-8 position, we have synthesized two new series of 6-aminoquinolones characterized by the presence of an Et or a methoxy group at C-8 position. The antibacterial evaluation shows that, while the 8-Et derivatives were devoid of any antibacterial activity, the introduction of methoxy group gave compounds with good antibacterial activity, especially against Gram-pos. bacteria. A tentative explanation of the different behaviors among the 8-substituted analogs is given taking into account both the length and electronic properties of the C-8 groups.
Bioorganic & Medicinal Chemistry published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Computed Properties of 924-99-2.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics