Al-Trawneh, Salah A. published the artcileSynthesis and cytotoxicity of thieno[2,3-b]pyridine derivatives toward sensitive and multidrug-resistant leukemia cells, Computed Properties of 924-99-2, the publication is Acta Chimica Slovenica (2021), 68(2), 458-465, database is CAplus and MEDLINE.
A new series of substituted Et 7-cyclopropyl-2-(2-aryloxo)-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylates I (R = H, CHO; X = H, 4-Me, 4-Cl; Y = O, S) were prepared by utilizing Et 2-chloro-7-cyclopropyl-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylate (1) and replacing of the 2-chlorine with anions obtained from phenol, salicylaldehyde derivatives like salicylaldehyde, 5-methylsalicylaldehyde and 5-chlorosalicylaldehyde or thiophenol, leading to the resp. Et 7-cyclopropyl-2-(2-aryloxo)-3-nitro-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxylates I. The new compounds I were evaluated for their in vitro cytotoxicity towards sensitive CCRF-CEM and multidrug-resistant CEM/ADR5000 leukemia cells. The screening revealed that compounds I (R = X = H, Y = O; R = CHO, X = H, Y = O; R = X = H, Y = S) inhibited the growth of both cell lines. Compound I (R = CHO, X = H, Y = O), with a phenol moiety, exhibited the highest growth inhibitory activity against CEM/ADR5000 and CCRF-CEM cells with IC50 values 4.486 ± 0.286 and 2.580 ± 0.550μM, resp. Collectively, the presented results demonstrate that the synthesized thieno[2,3-b]pyridines I warrant further exploration for potential use as anti-cancer agents.
Acta Chimica Slovenica published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Computed Properties of 924-99-2.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics