Al-Hiari, Yusuf M. published the artcileSynthesis and biological evaluation of substituted tetrahydro-1H-quino[7,8-b][1,4]benzodiazepine-3-carboxylic derivatives, Computed Properties of 924-99-2, the publication is Farmacia (Bucharest, Romania) (2014), 62(3), 570-588, database is CAplus.
This research paper aims the preparation of substituted tetrahydroquino[7,8-b][1,4]benzodiazepine-3-carboxylic acids I (R = F, Me, H2N). Reaction of 7-chloro-1-cyclopropyl-6-fluoro-8-nitro-1,4-dihydroquinoline-3-carboxylic acid with each of 2-amino-5-methylbenzoic acid, 2-amino-5-flourobenzoic acid, and 2-amino-5-nitrobenzoic acid yielded 8-nitro-7-substituted anilino-1,4-dihydroquinoline-3-carboxylic acids with low yields. Reduction of 8-nitro-7-substituted anilino-1,4-dihydroquinoline-3-carboxylic acids with sodium dithionite or stannous chloride resulted in the production of 8-amino-7-substituted aniline-1,4-dihydro-quinoline-3-carboxylic acids II. Polyphosphoric acid (PPA) catalyzed thermal lactamization of 8-amino-7-substituted aniline-1,4-dihydro-quinoline-3-carboxylic acids resulted in the production of I. The prepared targets and the intermediates have shown interesting antibacterial activity mainly against gram pos. strains. In particular, the reduced intermediates II showed good activity against standard S. aureus (MIC = 0.05 – 0.19 μg/mL). Intermediates II have also shown reasonable activity against resistant gram pos. strains. The targets I (R = F, H2N) have comparable activity to the reference against standard gram pos. strains.
Farmacia (Bucharest, Romania) published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C7H13NO2, Computed Properties of 924-99-2.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics