Takizawa, Toshiya published the artcileSynthetic studies on spiruchostatin A, a potent histone deacetylase inhibitor, Quality Control of 106391-88-2, the publication is Journal of Tohoku Pharmaceutical University (2007), 33-47, database is CAplus.
Spiruchostatin A (I), isolated from a culture broth of Pseudomonas sp., has been shown to be a potent histone deacetylase (HDAC) inhibitor. HDAC inhibitors can suppress the growth of human tumor xenografts, this natural product, therefore, is expected to be a promising candidate for novel mol.-targeted anticancer agents. We envisioned that I would be synthesized through twofold macrolactam/macrolactone cyclization of a fully elaborated acyclic disulfide. The key segments, required for the preparation of the advanced key intermediate, were initially synthesized, and the two segments were subsequently subjected to the critical cross S-S coupling reaction to produce a desired key intermediate. Upon deprotection of the N-Boc and the Me ester groups, the crucial cyclization formation was achieved using PyBOP to provide a desired macrolactam, a potential key precursor for I. Further investigations concerning the transformation of 16 to the target mol. I were also described.
Journal of Tohoku Pharmaceutical University published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C8H11NO, Quality Control of 106391-88-2.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics