Stimac, Vlado published the artcileInitial Scale-Up and Process Improvements for the Preparation of a Lead Antibacterial Macrolone Compound, Recommanded Product: Ethyl 3-(dimethylamino)acrylate, the publication is Organic Process Research & Development (2010), 14(6), 1393-1401, database is CAplus.
Macrolones are a novel class of potent antimicrobial agents that consist of a macrolide scaffold to which a quinolone unit is tethered by various linkers to the 4”-O-position of the cladinose sugar. In this paper is described a modified 13-step route to a lead compound in the series. Critical reaction steps in the medicinal chem. route were modified for an initial scale-up process, and as a result, a synthetic procedure suitable for preparation of multi-hundred gram quantities of the final product, with 98% purity, has been developed. The new procedure does not require any purification by column chromatog. for any of the reaction steps. The overall yield was increased from 5-8% in the medicinal chem. route to 27% in the improved procedure.
Organic Process Research & Development published new progress about 924-99-2. 924-99-2 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Amine,Aliphatic hydrocarbon chain,Ester, name is Ethyl 3-(dimethylamino)acrylate, and the molecular formula is C12H10FeO4, Recommanded Product: Ethyl 3-(dimethylamino)acrylate.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics