Sayar, Noel published the artcileFacile total synthesis of thailandepsins D-F: Novel bicyclic depsipeptide histone deacetylase inhibitors isolated from a microorganism, Safety of (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, the publication is Synthesis (2019), 51(6), 1419-1426, database is CAplus.
The naturally occurring bicyclic depsipeptide histone deacetylase inhibitors thailandepsins D-F were efficiently synthesized for the first time in 49-61% overall yield over five steps, starting from known amine and carboxylic acid segments. The synthesis includes the condensation of the two known starting materials to directly assemble the corresponding seco-acids, which are the key precursors for macrolactonization. The seco-acids are then macrolactonized using the Shiina method to construct the requisite 15-member macrocycles.
Synthesis published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C10H19NO3, Safety of (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate.
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