Ronsisvalle, Simone published the artcilePharmacological properties and biochemical mechanisms of μ-opioid receptor ligands might be due to different binding poses: MD studies, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one, the publication is Future Medicinal Chemistry (2020), 12(22), 2001-2018, database is CAplus and MEDLINE.
Central and peripheral analgesia without adverse effects relies on the identification of μ-opioid agonists that are able to activate basal antinociceptive pathways. Recently developed μ-selective benzomorphan agonists that are not antagonized by naloxone do not activate G-proteins and β-arrestins. Which pathways do μ receptors activate How can each of them be selectively activated What role is played by allosteric binding sites. Mol. modeling studies characterize the amino acid residues involved in the interaction with various classes of endogenous and exogenous ligands and with agonists and antagonists. Critical binding differences between various classes of agonists with different pharmacol. profiles have been identified. MML series binding poses may be relevant in the search for an antinociception agent without side effects.
Future Medicinal Chemistry published new progress about 517-23-7. 517-23-7 belongs to esters-buliding-blocks, auxiliary class Tetrahydrofuran,Ketone,Ester, name is 3-Acetyldihydrofuran-2(3H)-one, and the molecular formula is C6H8O3, Recommanded Product: 3-Acetyldihydrofuran-2(3H)-one.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics