Roberts, David C. published the artcileAcetoacetic ester condensation. XI. The extent of the condensation of certain monosubstituted acetic esters, HPLC of Formula: 5340-78-3, the publication is Journal of the American Chemical Society (1937), 2007-8, database is CAplus.
cf. C. A. 29, 6212.5. With 0.4 mol. EtONa and 2.4 mols. of ester, the following yields of RCH2COCHRCO2Et were obtained (at 95° except for R = H (78°)): R = H, 75-6% (based on EtONa); Me, 46-7; Et, 40-2; Pr, 34-35; Me2CH and Me3C, 0; Ph 53-5. Thus, the substitution of a normal alkyl group for one of the Me-H atoms of AcOEt progressively lowered the extent of the condensation as the size of the alkyl group increased. Sec. and tert substituents completely prevented the condensation, even under conditions that would allow the reaction to proceed to completion. PhCH2CO2Et condensed to a less extent than did AcOEt but to a considerably greater extent than did any of alkyl-substituted esters.
Journal of the American Chemical Society published new progress about 5340-78-3. 5340-78-3 belongs to esters-buliding-blocks, auxiliary class Aliphatic Chain, name is Ethyltert-butylacetate, and the molecular formula is C8H16O2, HPLC of Formula: 5340-78-3.
Referemce:
https://en.wikipedia.org/wiki/Ester,
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