Nakayama, Yasuhide published the artcileHigh performance gene delivery polymeric vector: Nano-structured cationic star polymers (star vectors), Recommanded Product: Benzyl diethylcarbamodithioate, the publication is Current Drug Delivery (2005), 2(1), 53-57, database is CAplus and MEDLINE.
Nano-structured hyperbranched cationic star polymers, called star vectors, were molecularly designed for a novel gene delivery non-viral vector. The linear and 3, 4 or 6 branched water-soluble cationic polymers, which had same mol. weight of ∼18,000, were synthesized by iniferter (initiator-transfer agent-terminator)-based photo-living-radical polymerization of 3-(N,N-dimethylamino)propyl acrylamide, initiated from resp. multi-dithiocarbamate-derivatized benzenes as an iniferter. All polymers produced polyion complexes ‘polyplexes’ by mixing with pDNA (pGL3-control plasmid), in which the particle size was ∼250 nm in diameter [the charge ratio < 2/1 (vector/pDNA)] and ∼150 nm (the charge ratio > 2.5/1), and the ζ-potential was ∼+10 mV (the charge ratio > 1/1). When COS-1 cells were incubated with the polyplexes 12h after preparation under the charge ratio of 5/1, higher gene expression was obtained as an increase in branching, with a little cytotoxicity. The relative gene expression to the linear polymer was about 2, 5, and 10 times in 3-, 4-, and 6-branched polymers, resp. The precise change in branching of polymers enabled the control of the gene transfer activity.
Current Drug Delivery published new progress about 3052-61-7. 3052-61-7 belongs to esters-buliding-blocks, auxiliary class Amine,Benzene,Amide, name is Benzyl diethylcarbamodithioate, and the molecular formula is C12H17NS2, Recommanded Product: Benzyl diethylcarbamodithioate.
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