Dhanoa, Daljit S. published the artcileThe synthesis of potent macrocyclic renin inhibitors, Related Products of esters-buliding-blocks, the publication is Tetrahedron Letters (1992), 33(13), 1725-8, database is CAplus.
An efficient synthesis of a novel class of potent macrocyclic renin inhibitors, exemplified by compounds I [R = Et, Bu, n-hexyl, morpholinomethyl, R1 = Boc-Phe; R = Bu, morpholinomethyl, R1 = (S)-Me3CSO2CH2CH(CH2Ph)CO; Boc = Me3CO2C], which involves the macrocyclization of glutamine derivative II as the key step, is described. The macrocyclic design of renin inhibitors I disclosed here incorporates (2R,3S)-3-amino-4-cyclohexyl-2-hydroxybutanoic acid as the transition-state isostere. Determination of stereochem. at the P2‘ position of the more potent diastereomer of the 13-membered cyclic renin inhibitors I [R = morpholinomethyl, R1 = PhCH2O2C, Boc-Phe, (S)-Me3CSO2CH2CH(CH2Ph)CO] is presented.
Tetrahedron Letters published new progress about 115314-17-5. 115314-17-5 belongs to esters-buliding-blocks, auxiliary class Epoxides,Chiral,Nitro Compound,Sulfonate,Benzene, name is (R)-Oxiran-2-ylmethyl 3-nitrobenzenesulfonate, and the molecular formula is C9H9NO6S, Related Products of esters-buliding-blocks.
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