Deng, Jifeng published the artcileThe highly potent and selective dipeptidyl peptidase IV inhibitors bearing a thienopyrimidine scaffold effectively treat type 2 diabetes, Recommanded Product: Methyl 2-amino-4-(trifluoromethyl)thiophene-3-carboxylate, the publication is European Journal of Medicinal Chemistry (2010), 46(1), 71-76, database is CAplus and MEDLINE.
Some dipeptidyl peptidase IV inhibitors, e.g., I, were designed based on alogliptin using a scaffold-hopping strategy. All of the compounds constructed on a thienopyrimidine scaffold demonstrated good inhibition and selectivity for DPP-IV. Compound I exhibited subnanomolar (IC50 = 0.33 nM) DPP-IV inhibitory activity, good in vivo efficacy and an acceptable pharmacokinetic profile. A pharmacokinetic-driven optimization of I may lead to a class of clin. candidate DPP-IV inhibitors.
European Journal of Medicinal Chemistry published new progress about 1094619-74-5. 1094619-74-5 belongs to esters-buliding-blocks, auxiliary class Trifluoromethyl,Thiophene,Fluoride,Amine,Ester, name is Methyl 2-amino-4-(trifluoromethyl)thiophene-3-carboxylate, and the molecular formula is C7H6F3NO2S, Recommanded Product: Methyl 2-amino-4-(trifluoromethyl)thiophene-3-carboxylate.
Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics